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Halofuginone hydrobromide
CAS No. : 64924-67-0
Biological Activity：Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
Research Area：Cancer|Infection|Inflammation/Immunology|Cardiovascular Disease
Targets：Parasite|Calcium Channel|DNA/RNA Synthesis|Sodium Channel|TGF-beta/Smad
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