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Icilin

CAS No. : 36945-98-9

Biological Activity：Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC₅₀=1.4 μM). Icilin is a “super-cooling agent”^[2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response^[3].

Research Area：Inflammation/Immunology|Neurological Disease

Targets：TRP Channel

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Mechanoreceptors Compound Library;Targeted Diversity Library;

Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;Palvanil;Pregnenolone monosulfate sodium-13C2,d2;Capsazepine;MSP-3;TRPM4-IN-2;Pregnenolone-d4-1;Umbellulone;DS88790512;TRPV antagonist 1;ML-SA1

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