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Marimastat

CAS No. : 154039-60-8

Biological Activity：Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC₅₀=3 nM), MMP-1 (IC₅₀=5 nM), MMP-2 (IC₅₀=6 nM), MMP-14 (IC₅₀=9 nM) and MMP-7 (IC₅₀=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes^[2].

Research Area：Cancer

Targets：MMP

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Human Metabolite Library;Anti-Pulmonary Fibrosis Compound Library;

Related Small Molecules:WAY-170523;CTTHWGFTLC, CYCLIC;Edaravone;D-Isofloridoside;Chondroitin sulfate;Ginsenoside F4;ND-336;Epitheaflagallin 3-O-gallate;Histatin 5 TFA;GW280264X;GI254023X;XL-784 free base;PI3K/AKT-IN-2;Diethyl-pythiDC;FN-439;ONO-4817;Isoliquiritin apioside;Anticancer agent 65;Licoricidin;Astragaloside IV;Phosphoramidon Disodium;Ilomastat;DB04760;Cipemastat;Dnp-PLGLWA-DArg-NH2 TFA;Cynaropicrin;Ro 31-9790

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