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SNIPER(ER)-87

CAS No. : 2222354-91-6

Biological Activity：SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC₅₀=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation^[2].

Research Area：Cancer

Targets：Estrogen Receptor/ERR|SNIPERs

Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;SNIPER(ABL)-039;Estriol-d3;Chrysin;ERRγ Inverse Agonist 1;(R)-DPN;MPP hydrochloride;GPR30 agonist-1;SNIPER(ABL)-049;Diethylstilbestrol;Endoxifen;Glicoricone;ERB-196;Dihydroresveratrol;FLTX1;(Rac)-Hexestrol-d6

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