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VBY-825

CAS No. : 1310340-58-9

Biological Activity：VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
IC50 value:
Target: 130/250/250/330/2.3/4.7 nM(Ki for cathepsin S/L/ZV/Bhumanized-rabbit cathepsin K/cathepsin F) [1]
VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

Research Area：Cancer

Targets：Cathepsin

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;

Related Small Molecules:Calpeptin;Cathepsin G Inhibitor I;Gly-Phe-β-naphthylamide;Z-FY-CHO;Balicatib;Cathepsin D and E FRET Substrate;N-CBZ-Phe-Arg-AMC TFA;LV-320;Z-LVG-CHN2;ONO-5334;L-873724;Z-WEHD-FMK;Odanacatib;Atg4B-IN-2;Cysteine Protease inhibitor;KGP94;E-64;Cathepsin L-IN-2;LmCPB-IN-1;MK-0674;MIV-247;Aurantiamide acetate;SID 26681509;ALLM;LY 3000328;Cathepsin C-IN-3;Cathepsin C-IN-5;K777

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