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Zamicastat
CAS No. : 1080028-80-3
Biological Activity：Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively. Zamicastat reduces high blood pressure[2].
Research Area：Cancer|Cardiovascular Disease
Targets：Dopamine β-hydroxylase|P-glycoprotein|BCRP
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Biricodar;Hypericin;PCI 29732;P-gp inhibitor 4;Sinapine thiocyanate;Dofequidar fumarate;Guanoclor;Triclabendazole sulfoxide;Elacridar;Coniferyl ferulate;P-gp/BCRP-IN-1;Anticancer agent 50;Valspodar;YHO-13351;P-gp inhibitor 1;Boeravinone B;Solamargine;Polyoxyethylene stearate;TTT-28;CP-100356 hydrochloride;EWP 815;PD166326;Epoxylathyrol;Chrysosplenetin;Fumitremorgin C;UR-MB108
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