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ACP-5862

CAS No. : 2230757-47-6

Biological Activity：ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC₅₀ of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC₅₀ of 3 nM and EC₅₀ of 8 nM^[2].

Research Area：Cancer

Targets：Drug Metabolite|Btk|Cytochrome P450

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:Nicotinamide N-oxide;SR9186;JAK3/BTK-IN-1;AMG-208;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;4-Hydroxyphenylbutazone;Ampyrone;Resveratrol-3-O-sulfate sodium;Elsubrutinib;Hypericin;Sonidegib metabolite M48;ARQ 531;Isonicotinic acid;PF-06250112;PCI 29732;Cycloguanil hydrochloride;Galeterone;Hydroxytanshinone IIA

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