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GW406108X

CAS No. : 1644443-92-4

Biological Activity：GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC₅₀ of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK^[2].

Research Area：Cancer

Targets：Autophagy|Kinesin|ULK

Related Screening Libraries:Natural Product-like Compound Library;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Cytoskeleton Compound Library;

Related Small Molecules:DB0614;Kif15-IN-1;EMD534085;K858 (Racemic);PF-2771;(Rac)-BL-918;Filanesib;ARQ 621;MRT68921 dihydrochloride;Kif15-IN-2;SBI-0206965;SB-743921 hydrochloride;Eg5 Inhibitor V, trans-24;BRD9876;ULK1-IN-2;DB1113;Monastrol;MRT67307 hydrochloride;AZ82;S-Trityl-L-cysteine;LYN-1604;Paprotrain;CW-069;SBP-7455;Litronesib Racemate

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