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Nonactin

CAS No. : 6833-84-7

Biological Activity：Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K⁺, and NH₄⁺. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin^[2]. Nonactin inhibits the surface expression of endogenous HSP60^[3].

Research Area：Cancer|Infection

Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Macrocyclic Compound Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;BJE6-106;Dinaciclib;Antibacterial agent 99;Ecteinascidin 770;MDM2-p53-IN-15

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