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Narazaciclib

CAS No. : 1357470-29-1

Biological Activity：Narazaciclib (ON123300), a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4 (IC₅₀=3.9 nM), Ark5 (IC₅₀=5 nM), PDGFRβ (IC₅₀=26 nM), FGFR1 (IC₅₀=26 nM), RET (IC₅₀=9.2 nM), and FYN (IC₅₀=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors^[2]. Narazaciclib inhibits CDK6 with an IC₅₀ of 9.82 nM^[3].

Research Area：Cancer

Targets：CDK|PDGFR|AMPK

Related Screening Libraries:Covalent Screening Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Antioxidant Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Angiogenesis-Related Compound Library;Lipid Metabolism Compound Library ;Glucose Metabolism Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:DB0614;AMPK activator 4;Dinaciclib;SNS-032;CC-671;(E/Z)-Zotiraciclib;CDK1-IN-4;Henatinib;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;Flumatinib mesylate;IHMT-TRK-284;T025;Flavopiridol;CDK8-IN-3;ZLN024;CDK9-IN-12;PDGFRα/FLT3-ITD-IN-2;YLF-466D;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX;Eciruciclib;PP58;BAY-3827

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