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hVEGF-IN-1
CAS No. : 1637443-98-1
Biological Activity：hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression.
Research Area：Cancer
Targets：VEGFR
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:(Z)-FeCP-oxindole;VEGFR-2-IN-24;BMS-690514;PROTAC VEGFR-2 degrader-2;Henatinib;PI3K/VEGFR2-IN-1;Hydroxytanshinone IIA;Chiauranib;Foretinib;ZM323881 hydrochloride;PTC299;ENMD-2076 Tartrate;Aflibercept;SU5408;MAZ51;R1530;AZD2932;R916562;XL092;Tyrosine kinase-IN-1;DMH4;Bucillamine
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