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NAZ2329

Biological Activity：NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC₅₀=7.5 µM for hPTPRZ1) and PTPRG (IC₅₀=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC₅₀ of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC₅₀ of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties.

Research Area：Cancer

Targets：Phosphatase

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Phosphatase Inhibitor Library;

Related Small Molecules:GNF362;ZLDI-8;Uralenol;SHP504;Trimyristin;SHP099 hydrochloride;MY10;PTP1B-IN-3 diammonium;Calyculin A;LMPTP inhibitor 1 dihydrochloride;[pTyr5] EGFR (988-993) (TFA);RMC-3943;AS1949490;PGAM1-IN-1;TD52 dihydrochloride;bpV(phen);EDP-305;CCT007093;(E/Z)-Icerguastat;ARL67156 trisodium;Cytostatin;SHP394;PTP1B-IN-4;EWP 815;PTP1B-IN-2;SHP389;NSC 663284;PSB-06126

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