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Garcinone C
CAS No. : 76996-27-5
Biological Activity：Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner.
Research Area：Cancer
Targets：CDK|STAT|ATM/ATR
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Natural Product Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Phenols Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Food-Sourced Compound Library ;Anti-Liver Cancer Compound Library ;Anti-Cancer Natural Product Library;Plant-Sourced Natural Product Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:DB0614;ATR-IN-16;Dinaciclib;Cirsilineol;ATR-IN-4;Ochromycinone;SNS-032;C188-9;CC-671;STAT3-IN-10;(E/Z)-Zotiraciclib;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;C188;Niclosamide monohydrate;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;CGK733;FLT3/CDK4-IN-1;GFB-12811;STAT3-IN-1;GSK 3 Inhibitor IX;STAT3 degrader-1;Eciruciclib;CDK-IN-6
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