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N-Methylmesoporphyrin IX
CAS No. : 142234-85-3
Biological Activity：N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies.
Research Area：Neurological Disease
Targets：G-quadruplex
Related Small Molecules:2-Di-1-ASP;MM41;L5-DA;360A;SOP1812;TMPyP4 tosylate;G4/HDAC-IN-1;Pyridostatin hydrochloride;BMVC;Carboxy pyridostatin trifluoroacetate salt;Nemorubicin;BMVC2
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