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PCS1055 dihydrochloride

CAS No. : 361979-40-0

Biological Activity：PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC₅₀ s of 22 nM and 120 nM for electric eel and human AChE, respectively^[2].

Research Area：Neurological Disease

Targets：mAChR|Cholinesterase (ChE)

Related Small Molecules:VU0357017 hydrochloride;TBPB;Imidafenacin;Sabcomeline;Piperilate;MK-6884;BuChE-IN-5;Brompheniramine-d6 maleate;AChE/BChE-IN-10;Timosaponin AIII;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11;Navafenterol saccharinate;Heliosupine;(-)-Cyclopenin

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