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Avatrombopag hydrochloride

CAS No. : 570403-17-7

Biological Activity：Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A^[2][3].

Research Area：Cardiovascular Disease

Targets：Thrombopoietin Receptor

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Avatrombopag-d8 hydrochloride;Rafutrombopag diolamine;Lusutrombopag-d13;Lusutrombopag;Rafutrombopag;Hetrombopag;TPO agonist 1

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