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GSK8814

CAS No. : 1997369-78-4

Biological Activity：GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pK_d=8.1 and a pK_i=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC₅₀s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.

Research Area：Cancer

Targets：Epigenetic Reader Domain

Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Chemical Probe Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:RVX-297;BRD4 Inhibitor-19;UNC6349 (Ket2);Curcumin;GSK6853;GSK4028;SR-0813;Inobrodib;Apabetalone;OF-1;I-CBP112;A-485;PLX51107;FKBP12 PROTAC dTAG-7;I-BET151;GSK040;BRM/BRG1 ATP Inhibitor-4;PBRM1-BD2-IN-5;MI-136;IACS-9571;SF2523;L-Moses dihydrochloride;KB02-JQ1;GSK620;INCB-057643;Bromodomain IN-1;QCA570;BRM/BRG1 ATP Inhibitor-1;Ziftomenib

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