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PF-06424439 methanesulfonate

CAS No. : 1469284-79-4

Biological Activity：PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC₅₀ of 14 nM. PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate^[2].

Research Area：Metabolic Disease

Targets：Acyltransferase

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Obesity Compound Library;Lipid Metabolism Compound Library ;Targeted Diversity Library;

Related Small Molecules:RP-64477;Enniatin A;IWP-12;ABT-046;PF-04620110;ACAT-IN-5;TP-020;Diacylglycerol acyltransferase inhibitor-1;JNJ-DGAT2-A;DGAT-1 inhibitor 2;Lateritin;OSMI-3;Avasimibe;Nevanimibe hydrochloride;FCE 28654;YM17E;RP 70676;ACAT-IN-3;Pactimibe;Pradigastat;CP-113818;VULM 1457;A 922500;ACAT-IN-6;AZD3988;T863;PF-06471553;ESI-05;Fumonisin B1

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