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EN6

CAS No. : 1808714-73-9

Biological Activity：EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner.

Research Area：Neurological Disease

Targets：Autophagy

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Autophagy Compound Library;Anti-Aging Compound Library;Covalent Screening Library;

Related Small Molecules:Physalin A;Stauprimide;Pregnenolone monosulfate sodium;Notoginsenoside Fc;AGN 193109-d7;AT9283;Ciclopirox-d11;BIX-01294;Wogonoside;Cyclovirobuxine D;Clotrimazole-d5;Curcumin;Loperamide-d6 N-Oxide;Physalin B;Colistin sulfate;Salvianolic acid B;10074-G5;Dehydrocorydaline;Glucosamine-13C hydrochloride

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