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Calcimycin hemicalcium salt

CAS No. : 59450-89-4

Biological Activity：Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis^[2]^[3]^[4].

Research Area：Cancer|Infection

Targets：Fungal|Autophagy|Bacterial|Antibiotic|Apoptosis

Related Small Molecules:Antifungal agent 20;Physalin A;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Debneyol;Leucomycin;Isouvaretin;BJE6-106;Dinaciclib;Haloprogin

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