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NLRP3-IN-NBC6

CAS No. : 2068818-02-8

Biological Activity：NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC₅₀= 574 nM) that acts independently of Ca²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Research Area：Inflammation/Immunology

Targets：NOD-like Receptor (NLR)

Related Small Molecules:MCC950;Dapansutrile;NOD-IN-1;NLRP3-IN-4;NLRP3-IN-12;Nigericin;NLRP3-IN-5;β-Aminoarteether;GSK717;Selnoflast;NOD1/2 antagonist-1;BMS-986299;NDT-30805;Licochalcone B;Emlenoflast sodium;AMS-17;NLRP3-IN-6;CY-09;NLRP3/AIM2-IN-1;Muscone;NLRP3-IN-8;INF4E;NLRP3-IN-2

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