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N-piperidine Ibrutinib hydrochloride
CAS No. : 2231747-18-3
Biological Activity：N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2].
Research Area：Cancer
Targets：Ligands for Target Protein for PROTAC|Btk
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Blood Cancer Compound Library;Target Protein Ligand Library;
Related Small Molecules:JAK3/BTK-IN-1;Elsubrutinib;ARQ 531;PF-06250112;PCI 29732;BI-4464;PROTAC BRD4 ligand-2;PROTAC BRD9-binding moiety 1 hydrochloride;PROTAC IRAK4 ligand-1;Apcin-A;CHMFL-EGFR-202;Avitinib;RN486;GDC-0834 Racemate;Spebrutinib besylate;Vecabrutinib;BMX-IN-1;Tolebrutinib;Ipatasertib-NH2 dihydrochloride;BTK-IN-16;(R)-Zanubrutinib;SirReal1-O-propargyl;Pirtobrutinib;CTA056;PD0325901-O-C2-dioxolane
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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