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JH-RE-06
CAS No. : 1361227-90-8
Biological Activity：JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[2].
Research Area：Cancer
Targets：DNA/RNA Synthesis
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:Ametantrone;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;P1788;Thymidine-13C5,15N;NSC 617145;116-9e;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;6-Thio-2′-Deoxyguanosine;Antitumor agent-74;Risdiplam;TH287 hydrochloride;Direct Black 38;7-TFA-ap-7-Deaza-ddA;BCH001;NKP-1339;Fialuridine;2′-O-MOE-5-Me-rC;PTC299;2′-F-Bz-dC Phosphoramidite
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