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CCG258747
CAS No. : 2615910-00-2
Biological Activity：CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure.
Research Area：Cardiovascular Disease
Targets：Opioid Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Kinase Inhibitor Library;Neuronal Signaling Compound Library;Anti-Cardiovascular Disease Compound Library;Neurotransmitter Receptor Compound Library;Anti-Obesity Compound Library;Lipid Metabolism Compound Library ;
Related Small Molecules:ORL1 antagonist 1;Loperamide-d6 N-Oxide;Deltorphin 2 TFA;Nalfurafine;β-Lipotropin (60-65);GSK1521498 free base;Trimebutine-d5 fumarate;Dynorphin B (1-13) (TFA);Dermorphin Analog;β-Endorphin (6-31), human;JTC-801;Valorphin;Corydaline;TAN-452;Matrine;Naloxonazine dihydrochloride;[Leu5]-Enkephalin;Sec-O-Glucosylhamaudol;DPDPE;EST73502;CTOP;β-Endorphin, equine;Tyr-W-MIF-1;Nociceptin (1-13), amide TFA;Morphiceptin;[Nphe1]Nociceptin(1-13)NH2;UFP-101
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