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Oxaprozin

CAS No. : 21256-18-8

Biological Activity：Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties^[2].

Research Area：Inflammation/Immunology|Cancer

Targets：Akt|NF-κB|IKK|Apoptosis|COX

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Anti-COVID-19 Compound Library;NMPA-Approved Drug Library;Glycolysis Compound Library;Pyroptosis Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Cancer Stem Cells Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;COX-2/5-LOX-IN-3;Lobetyolin;Icariside F2;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;IKKγ NBD Inhibitory Peptide TFA;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9

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