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LE135
CAS No. : 155877-83-1
Biological Activity：LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC50s of 2.5 μM and 20 μM, respectively[2].
Research Area：Cancer|Neurological Disease
Targets：RAR/RXR|TRP Channel
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;Neuronal Signaling Compound Library;Anti-Cancer Compound Library;Anti-Blood Cancer Compound Library;Transcription Factor-Targeted Library;Mechanoreceptors Compound Library;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;Nuclear Receptor Compound Library;
Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;AGN 193109-d7;TRPC5-IN-4;OptoBI-1;Retinoic acid;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;AC-261066;Palvanil;Magnolol;ER 50891;(+)-Talarozole
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