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JH-X-119-01

CAS No. : 2227368-54-7

Biological Activity：JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC₅₀ of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM^[2].

Research Area：Cancer|Infection|Inflammation/Immunology

Targets：IRAK

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:IRAK4-IN-8;Edecesertib;IRAK4-IN-22;IRAK inhibitor 2;PROTAC IRAK4 degrader-3;IRAK inhibitor 6;GNE-2256;IRAK4-IN-14;PROTAC IRAK4 degrader-1;HG-12-6;IRAK4-IN-19;IRAK4-IN-6;KTX-582;IRAK4-IN-11;HS271;IRAK-4 protein kinase inhibitor 2;PROTAC IRAK4 degrader-6;IRAK4-IN-17;Ginsenoside Rb1;Zabedosertib;IRAK4-IN-12;IRAK-1-4 Inhibitor I;IRAK4-IN-15;IRAK inhibitor 3;PROTAC IRAK4 degrader-7;KTX-955;Zimlovisertib;KTX-497

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