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A-366
CAS No. : 1527503-11-2
Biological Activity：A-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively. A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families[2][3][4].
Research Area：Cancer
Targets：Epigenetic Reader Domain|Histone Methyltransferase
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Chemical Probe Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:RVX-297;BRD4 Inhibitor-19;EEDi-5285;EZH2-IN-2;UNC6349 (Ket2);BIX-01294;Curcumin;GSK6853;GSK4028;SR-0813;SGC707;Inobrodib;(S)-HH2853;G9a-IN-1;UNC4976;Apabetalone;MS1943;OF-1;I-CBP112;OTS186935 hydrochloride;A-485;PLX51107;FKBP12 PROTAC dTAG-7;I-BET151;MS8815;(R)-HH2853;EPZ020411;GSK040;Furamidine dihydrochloride
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