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Epalrestat

CAS No. : 82159-09-9

Biological Activity：Epalrestat is an aldose reductase inhibitor for the treatment of diabetic neuropathy.
Target: Aldose Reductase
Epalrestat may affect or delay progression of the underlying disease process. Data from six clinical trials were evaluated, and it was determined that epalrestat 50 mg 3 times/day may improve motor and sensory nerve conduction velocity and subjective neuropathy symptoms as compared with baseline and placebo. Epalrestat may serve as a new therapeutic option to prevent or slow the progression of diabetic neuropathy [1]. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis [2]. Epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy [3].

Research Area：Metabolic Disease

Targets：Aldose Reductase

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Related Small Molecules:Exisulind;Aldose reductase-IN-6;Danshenol A;Ganoderic acid C6;Ponalrestat;Imirestat;Risarestat;Zopolrestat;ALR2-IN-1;EBPC;Hydroxyevodiamine;Zenarestat;Poliumoside;Aldose reductase-IN-3;Sorbinil;ALR2-IN-2;Aldose reductase-IN-2;Fidarestat;Alrestatin sodium;Tolrestat;Caficrestat;Aldose reductase-IN-4;AT-007;Myrciacetin;Soyasaponin Ba;ALR1/2-IN-1;Aldose reductase-IN-5

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