For research use only. We do not sell to patients.
PROTAC EGFR degrader 4
Biological Activity：PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy.
Research Area：Cancer
Targets：EGFR|Autophagy|PROTACs
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;Osimertinib-13C,d3;EGFR-IN-5;FGFR2-IN-3;HDAC6 degrader-1;PROTAC Axl Degrader 2;PhosTAC7;MS98;Genistein;Epertinib hydrochloride;JPS014;PROTAC PARP1 degrader;UNC-CA359;MD-224;FKBP12 PROTAC dTAG-7;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;Falnidamol;SJ10542
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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