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PF-03715455

CAS No. : 1056164-52-3

Biological Activity：PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC₅₀ values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC₅₀=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)^[2].

Research Area：Inflammation/Immunology

Targets：p38 MAPK

Related Small Molecules:SB-747651A dihydrochloride;Dehydrocorydaline;SKF-86002 dihydrochloride;Pexmetinib;SB 242235;TA-01;Anti-inflammatory agent 7;MW-150;VX-702;R1487 Hydrochloride;MBP MAPK Substrate;Isoliquiritin apioside;Sesamolin;MAPK13-IN-1;PF-05381941;Semapimod tetrahydrochloride;SD-169;Skatole;BMS-582949 hydrochloride;Gypenoside L;Dilmapimod;Pamapimod;Andrograpanin;MKK7-COV-9;AMG-47a;Kaempferol-3-O-glucorhamnoside;SB 202190 hydrochloride

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