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VULM 1457
CAS No. : 228544-65-8
Biological Activity：VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM 1457 has the potential for the research of diabetes mellitus and hypercholesterolaemia[2].
Research Area：Metabolic Disease|Cardiovascular Disease
Targets：Acyltransferase
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-diabetic Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Lipid Metabolism Compound Library ;Human Metabolite Library;
Related Small Molecules:RP-64477;Enniatin A;IWP-12;ABT-046;PF-04620110;ACAT-IN-5;TP-020;Diacylglycerol acyltransferase inhibitor-1;JNJ-DGAT2-A;DGAT-1 inhibitor 2;Lateritin;OSMI-3;Avasimibe;Nevanimibe hydrochloride;FCE 28654;YM17E;RP 70676;ACAT-IN-3;Pactimibe;Pradigastat;CP-113818;A 922500;ACAT-IN-6;AZD3988;T863;PF-06471553;ESI-05;Fumonisin B1
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