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DLK-IN-1
CAS No. : 1620574-24-4
Biological Activity：DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.
Research Area：Neurological Disease
Targets：MAP3K
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Oxygen Sensing Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;
Related Small Molecules:TAK1-IN-2;ASK1-IN-3;Takinib;PF-05381941;SM1-71;NQDI-1;GS-444217;TC ASK 10;7,3′,4′-Trihydroxyisoflavone;TAK1-IN-4;Selonsertib;Cot inhibitor-1;TAK1/MAP4K2 inhibitor 1;5Z-7-Oxozeaenol;Tpl2 Kinase Inhibitor 1;SW083688;Cot inhibitor-2;ASK1-IN-2;TAO Kinase inhibitor 1;GNE-8505;GNE-3511;NG25;TAK1-IN-3
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