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Trk-IN-10

CAS No. : 2700265-61-6

Biological Activity：Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC₅₀ = 0.86, 6.92 nM, against TrkA, TrkA^G595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC₅₀ = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.

Research Area：Cancer

Targets：Trk Receptor

Related Small Molecules:hTrkA-IN-1;IHMT-TRK-284;ANA-12;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;LM22B-10;D5261;N-Acetyl-5-hydroxytryptamine-d3;7,8-Dihydroxyflavone;TRK-IN-18;TRK-IN-12;CH7057288;Entrectinib;Pan-Trk-IN-3;ONO-7475;AZ-23;Trk-IN-6;GNF-5837;Cyclotraxin B;TrkA-IN-1;PF-06737007;TRK II-IN-1;Trk-IN-9;Trk-IN-1;Sacibertinib;Pan-Trk-IN-2;TRK-IN-13

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