FNDR-20123

For research use only. We do not sell to patients.

FNDR-20123

Biological Activity:FNDR-20123 is a safe, first-in-class, and orally active anti-malarial HDAC inhibitor with IC50s of 31 nM and 3 nM for Plasmodium and human HDAC, respectively. FNDR-20123 exerts anti-malarial activity against Plasmodium falciparum asexual stage (IC50=41 nM) and sexual blood stage (IC50=190 nM for male gametocytes). FNDR-20123 inhibits HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 (IC50=25/29/2/11/282 nM, respectively.) and inhibits Class III HDAC isoforms at nanomolar concentrations.

Research Area:Infection

Targets:Parasite|HDAC

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Orally Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Antiparasitic Compound library;Anti-Liver Cancer Compound Library ;Osteogenesis Compound Library;

Related Small Molecules:(+)-Isopulegol;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;SQ109;Trypanothione synthetase-IN-3;Pivanex;Pyrantel;α-Terpinene;Dehydrocorydaline;Crotonoside;MPT0B390;Niclosamide monohydrate;Febrifugine dihydrochloride;Antimalarial agent 15;RSC133;Cycloguanil hydrochloride;Anti-infective agent 6;HDAC1/6-IN-1;HDAC/HSP90-IN-4;Morantel tartrate;JPS014

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