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Telaglenastat

CAS No. : 1439399-58-2

Biological Activity：Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.

Research Area：Cancer

Targets：Autophagy|Glutaminase

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound Library;Drug Repurposing Compound Library;Ferroptosis Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Cuproptosis Compound Library;

Related Small Molecules:TG-2-IN-1;A-446;BPTES-d10;UPGL00004;IPN60090;GLS1 Inhibitor-6;Glutaminase C-IN-1;Glutaminase-IN-1;Cystamine (dihydrochloride）;GLS1 Inhibitor-4;KCC009;GK921;NTU281;Glutaminase-IN-4;GLS-1-IN-1;6-Diazo-5-oxo-L-nor-Leucine;ZED-1227;2-Amino-2-(p-tolyl)acetic acid;BPTES;GLS1 Inhibitor-3;Glutaminase-IN-3;JHU-083;GLS1 Inhibitor-5;L-Albizziin;α-Glucosidase-IN-5

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