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PK11000
CAS No. : 38275-34-2
Biological Activity：PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities.
Research Area：Cancer
Targets：DNA Alkylator/Crosslinker|MDM-2/p53
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Transcription Factor-Targeted Library;Anti-Colorectal Cancer Compound Library ;
Related Small Molecules:MDM2-p53-IN-15;MC-VC-PABC-SP 141;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;Anticancer agent 11;Tesirine;DC10SMe;MD-224;Duocarmycin TM;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;p-nitro-Pifithrin-α;RG7112;MMRi62;Anticancer agent 50;NSC59984;Pifithrin-β hydrobromide;Ivaltinostat formic;GEM-5;Prednimustine;Sibiromycin;Tenovin-6;PK11007
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