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R406 free base
CAS No. : 841290-80-0
Biological Activity：R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
Research Area：Inflammation/Immunology|Cancer
Targets：FLT3|Apoptosis|Syk
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-diabetic Compound Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10;(E/Z)-Zotiraciclib
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