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PD180970
CAS No. : 287204-45-9
Biological Activity：PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research[2][3].
Research Area：Cancer|Neurological Disease
Targets：Bcr-Abl|Src|c-Kit|Apoptosis
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