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SEN177
CAS No. : 2117405-13-5
Biological Activity：SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a Ki of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates. SEN177 has the potential for Huntington’s disease research.
Research Area：Neurological Disease
Targets：Amyloid-β
Related Screening Libraries:Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;
Related Small Molecules:β-Amyloid (13-27);Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);BuChE-IN-5;Ginsenoside Rg1;MDR-1339;β-Amyloid (11-22);20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;γ-Secretase modulator 12;δ-Secretase inhibitor 11;BuChE-IN-2;FPS-ZM1;BChE-IN-8;4-(6-Bromo-2-benzothiazolyl)benzenamine;Timosaponin BII;Valiltramiprosate;Azeliragon;CRANAD-2
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