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A-9758
CAS No. : 2055271-22-0
Biological Activity：A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation.
Research Area：Inflammation/Immunology
Targets：Interleukin Related|ROR
Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;AX-024;RORγt inverse agonist 30;GNE-0946;Ginsenoside F3;Perakizumab;RORγt inverse agonist 13;PNRI-299;CTX-471;Ac-YVAD-CHO;Deucravacitinib;Vimirogant hydrochloride;SR2211;Bevurogant;Mulberroside A;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;ROR agonist-1;RORγt Inverse agonist 8;5(S)15(S)-DiHETE;IL-17A inhibitor 2;Anti-Mouse IL-1b Antibody;Raleukin;Ossirene;VGX-1027
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