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BQ-123 TFA
Biological Activity：BQ-123 TFA is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 TFA inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension[2][3].
Research Area：Cardiovascular Disease
Targets：Endothelin Receptor
Related Small Molecules:BQ-788;[Asn18] Endothelin-1, human;Endothelin-3, human, mouse, rabbit, rat TFA;IRL 2500;Sarafotoxin S6c;Sarafotoxin S6a;ANP (1-30), frog;IRL-1620 TFA;Tezosentan;ACT-373898;Ro 46-2005;Ro 46-8443;[Ala2] Endothelin-3, human;ZD-1611;PD-159020;Aminaftone;Aprocitentan-d4;Endothelin 1 (swine, human);Atrial Natriuretic Peptide (ANP) (1-28), rat;Carperitide acetate;[Ala1,3,11,15]-Endothelin (53-63) (TFA);Sparsentan-d5
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