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Licochalcone B

CAS No. : 58749-23-8

Biological Activity：Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction^[2][3][4].

Research Area：Neurological Disease

Targets：Amyloid-β|NOD-like Receptor (NLR)|Apoptosis

Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Neuronal Signaling Compound Library;NF-κB Signaling Compound Library;Natural Product Library;Antioxidant Compound Library;Lipid Compound Library;Oxygen Sensing Compound Library;Medicine Food Homology Compound Library;Pyroptosis Compound Library;Traditional Chinese Medicine Active Compound Library;Flavonoids Library;Anti-Alzheimer’s Disease Compound Library;Anti-Lung Cancer Compound Library;Neurodegenerative Disease-related Compound Library;Food-Sourced Compound Library ;Anti-Cancer Natural Product Library;Antidepressant Compound Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Human Metabolite Library;

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