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RBC8
CAS No. : 361185-42-4
Biological Activity：RBC8 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.5 μM in H2122 cell and 3.4 μM in H358 cell.
IC50 value:
Target: Ral GTPase inhibitor
RBC8 or BQU57 treatment showed no further inhibition of colony formation after Ral knockdown. RBC8 and BQU57 showed favorable properties that define good drug candidates. To test the effect of Ral inhibitors on xenograft tumor growth, nude mice were inoculated subcutaneously with H2122 human lung cancer cells and treated intraperitoneally with 50 mg/kg/d of RBC8 for 21 days (except weekends). RBC8 inhibited tumor growth to a similar extent as dual knockdown of RalA and RalB.
Research Area：Cancer
Targets：Ras
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Ferroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;
Related Small Molecules:Deltarasin hydrochloride;ZINC09659342;KRAS G12C inhibitor 56;CCG-232601;KRAS G12D inhibitor 14;1A-116;KRAS G12D inhibitor 10;KRAS G12C inhibitor 20;KRAS G12C inhibitor 24;RM-018;KRAS G12C inhibitor 14;APS6-45;6H05;KRpep-2d TFA;KRAS G12C inhibitor 33;KRAS G12C inhibitor 53;K-Ras-IN-1;KRAS G12C inhibitor 41;KRAS G12C inhibitor 26;KRAS G12C inhibitor 16;KRAS inhibitor-11;SOS1-IN-13;BQU57;ZCL278;Digeranyl bisphosphonate;KRAS inhibitor-7;SOS1 activator 1;KRAS inhibitor-14;SAH-SOS1A
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