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Glyburide-d11
CAS No. : 1189985-02-1
Biological Activity：Glyburide-d11 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
Research Area：Metabolic Disease
Targets：CFTR|Autophagy|Potassium Channel|P-glycoprotein|Mitochondrial Metabolism
Related Small Molecules:PG01;Kv3 modulator 2;CFTR corrector 8;MitoTam bromide, hydrobromide;Biricodar;Brompheniramine-d6 maleate;Pinacidil;CP-628006;AMP-PNP tetralithium;P-gp inhibitor 4;IK1 inhibitor PA-6;MitoTEMPO hydrate;NL-1;VU590;Sinapine thiocyanate;Domiphen bromide;Thiabendazole-d4;Mesoridazine benzenesulfonate;Dofequidar fumarate;Tetrandrine;20(S)-Ginsenoside Rg3;Elacridar;Coniferyl ferulate
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