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ODN 2216

CAS No. : 332437-00-0

Biological Activity：ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4⁺ T cells^[2]^[3]^[4].

Research Area：Cancer|Infection|Inflammation/Immunology

Targets：IFNAR|Interleukin Related|Toll-like Receptor (TLR)

Related Screening Libraries:Bioactive Compound Library Plus;

Related Small Molecules:C29;AX-024;TMX-201;Cirsilineol;Ginsenoside F3;Perakizumab;RS 09;ODN 20844;PNRI-299;TLR7/8-IN-1;TLR8 agonist 5;CTX-471;Ac-YVAD-CHO;Deucravacitinib;Sulfo-ara-F-NMN;TLR7/8 antagonist 1;Gardiquimod;PF-4878691;Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH;Mulberroside A;Pepinh-TRIF TFA;Afimetoran;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;Schaftoside

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