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VP3.15 dihydrobromide
CAS No. : 1281681-33-1
Biological Activity：VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).
Research Area：Neurological Disease
Targets：Phosphodiesterase (PDE)|GSK-3
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Metabolism/Protease Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Glucose Metabolism Compound Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;TCS2002;ATX inhibitor 22;Carbazeran citrate;AR-A014418;Bay 60-7550;BC11-38;Deltarasin hydrochloride;Glaucine;Ziritaxestat;Udenafil-d7;D159687;GSK 3 Inhibitor IX;ITI-214;PDE10-IN-5;ICI 153110;Furamidine dihydrochloride;ML-030;MeBIO;PDE4-IN-10;Mirodenafil-d7 dihydrochloride;PDE1-IN-4;PDE4B-IN-3;Cromolyn-d5 sodium;GS87;Cirsimarin
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