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RO2959 hydrochloride

CAS No. : 1219927-22-6

Biological Activity：RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways^[2].

Research Area：Cardiovascular Disease

Targets：Interleukin Related|CRAC Channel

Related Small Molecules:AX-024;Ginsenoside F3;Perakizumab;PNRI-299;CTX-471;Ac-YVAD-CHO;Deucravacitinib;Mulberroside A;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;5(S)15(S)-DiHETE;IL-17A inhibitor 2;Anti-Mouse IL-1b Antibody;Raleukin;5J-4;Ossirene;VGX-1027;RCGD423;Clazakizumab;Reslizumab;Gamma-glutamylcysteine TFA;Tyrphostin A1;Interleukin (IL)-6 Receptor;Satralizumab;Sirukumab

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