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SMTIN-T140

Biological Activity：SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC₅₀ of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells.

Research Area：Cancer

Targets：Reactive Oxygen Species|HSP|AMPK

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose heptahydrochloride;AMPK activator 4;N-Acetyl-D-cysteine;Topoisomerase I/II inhibitor 3;CYPMPO;Antioxidant agent-5;6BrCaQ;ROS-ERS inducer 1;Glucosamine-13C hydrochloride;L-Ascorbic acid sodium salt;D-Isofloridoside;116-9e;L-Carnitine-d3 hydrochloride;Licochalcone D;ZLN024;YLF-466D;Euparin;RH-EDA;Paeoniflorin;HDAC/HSP90-IN-4;Debio 0932;1,3-Dicaffeoylquinic acid;Antitumor agent-68;Echinocystic acid;Glucosamine-13C6,15N hydrochloride;PI3Kα-IN-8;BAY-3827

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