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PF-5274857

CAS No. : 1373615-35-0

Biological Activity：PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC₅₀ of 5.8 nM and K_i of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

Research Area：Cancer

Targets：Smo

Related Screening Libraries:Bioactive Compound Library Plus;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;

Related Small Molecules:Saikosaponin B1;MRT-10;LEQ506;RL-0070933;20(S)-Hydroxycholesterol;Sonidegib;PF-5274857 hydrochloride;MRT-83 hydrochloride;TPB15;CUR61414;SANT-1;SAG-d3;SMANT hydrochloride;BMS-833923;SMO-IN-2;SMO-IN-1;IHR-1;Purmorphamine (GMP);IHR-Cy3;MRT-14;MK-4101;SAG hydrochloride;DY131

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